SNX7

Across TCGA patient cohorts, SNX7 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX7-associated genes across cancer lineages are c-Met_pY1235, eEF2, and A-Raf_pS299. Each is linked with SNX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX7-to-partner and partner-to-SNX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by SNX7-low versus SNX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX7→partner) and Y-score (partner→SNX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.068	+2.000	.041	.032	3	2
UCEC	eEF2 →	+0.428	+2.000	.007	.032	3	1
UCEC	A-Raf_pS299 →	-0.116	-3.000	.031	.036	3	1
UCEC	ERK2 →	+0.248	+2.321	.004	.033	3	1
UCEC	INPP4B →	-0.347	-3.169	.017	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.221	-3.794	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

c-Met_pY1235 by SNX7 expression — UCEC

Explore this box plot interactively →