SNX5

Across TCGA patient cohorts, SNX5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX5-associated genes across cancer lineages are Ku80, mTOR, and STAT3_pY705. Each is linked with SNX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX5-to-partner and partner-to-SNX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SNX5-low versus SNX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX5→partner) and Y-score (partner→SNX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.336	+3.009	.004	.019	3	1
UCEC	mTOR →	-0.205	-2.321	.011	.035	3	1
UCEC	STAT3_pY705 →	-0.447	-2.321	<.001	.035	3	1
UCEC	Tuberin →	+0.344	+2.321	.011	.035	3	1
UCEC	VHL →	-1.043	-3.459	.002	.005	3	1
UCEC	Caspase-8 →	-0.262	-2.973	.037	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by SNX5 expression — UCEC

Explore this box plot interactively →