SNX5

Across TCGA cell cohorts, SNX5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX5-associated genes across cancer lineages are C12orf40, GJD2, and MMP26. Each is linked with SNX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX5-to-partner and partner-to-SNX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by SNX5-low versus SNX5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX5→partner) and Y-score (partner→SNX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	CCR8 →	+0.167	+3.554	<.001	.007	3	1
LARGE_INTESTINE	GYPE →	+0.013	+3.878	.005	.003	3	1
LARGE_INTESTINE	KLK9 →	+0.145	+3.878	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C12orf40 by SNX5 expression — OVARY

Explore this box plot interactively →