SNX4

Across TCGA pan-cancer cohorts, SNX4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SNX4 data layer compared with 26 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SNX4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNX4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, PRAD, and LUAD are the cancer types where SNX4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.051	0.720	<.001	48	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	OS	Median	III,IV	0.228	0.677	.015	6	view →
SKCM	OS	Median	All	0.501	0.787	.037	4	view →
UCEC	DFS	Median	All	0.957	0.627	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SNX4–BLCA (OS)

Open the BLCA breakdown →