SNX4

Across TCGA pan-cancer cohorts, SNX4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SNX4 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SNX4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SNX4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where SNX4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.887	0.283	.012	31	view →
UCEC	DFS	Quartile	All	1.000	0.775	.002	26	view →
HNSC	OS	Median	All	0.449	1.000	.023	23	view →
PDAC	DFS	Quartile	II,III,IV	0.492	0.249	.002	14	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.920	.047	12	view →
LUAD	OS	Quartile	II,III,IV	0.680	0.298	.009	12	view →
GBM	OS	Quartile	All	0.275	0.644	.017	4	view →
LSCC	OS	Median	All	0.919	0.825	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SNX4–CCRCC (DFS)

Open the CCRCC breakdown →