SNX33

Across TCGA patient cohorts, SNX33 mutation is significantly associated with the RNA expression of many other genes, with 1,845 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX33-associated genes across cancer lineages are VPS26B, TGM7, and SDC3. Each is linked with SNX33 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX33-to-partner and partner-to-SNX33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS26B grouped by SNX33-low versus SNX33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX33→partner) and Y-score (partner→SNX33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VPS26B →	+0.432	+3.032	<.001	<.001	3	2
UCEC	TGM7 →	+0.769	+1.954	.009	.008	3	2
UCEC	SDC3 →	+0.528	+3.470	.007	.002	3	2
UCEC	PNPLA6 →	+0.536	+3.056	<.001	<.001	3	2
UCEC	ACTB →	+0.593	+2.736	<.001	<.001	3	2
UCEC	PER1 →	+0.580	+2.769	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,845 associations by consensus.

VPS26B by SNX33 expression — UCEC

Explore this box plot interactively →