SNX33

Across TCGA patient cohorts, SNX33 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX33-associated genes across cancer lineages are GAPDH, eEF2, and ERK2. Each is linked with SNX33 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNX33-to-partner and partner-to-SNX33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SNX33-low versus SNX33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX33→partner) and Y-score (partner→SNX33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.506	+2.000	.016	.030	3	3
UCEC	eEF2 →	+0.396	+3.459	.004	.005	3	2
UCEC	ERK2 →	+0.213	+3.321	.004	.009	3	2
UCEC	Notch1 →	+0.134	+2.000	.015	.010	3	2
UCEC	p62 Lck ligand →	+0.393	+2.125	.002	.010	3	2
UCEC	14-3-3_beta →	-0.101	-3.143	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

GAPDH by SNX33 expression — UCEC

Explore this box plot interactively →