SNX33

Across TCGA cell cohorts, SNX33 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX33-associated genes across cancer lineages are HPCAL4, FCN2, and CDC20B. Each is linked with SNX33 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX33-to-partner and partner-to-SNX33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPCAL4 grouped by SNX33-low versus SNX33-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX33→partner) and Y-score (partner→SNX33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HPCAL4 →	+0.430	+3.392	<.001	.004	3	1
LARGE_INTESTINE	FCN2 →	+0.025	+3.678	<.001	.001	3	1
LARGE_INTESTINE	CDC20B →	+0.065	+3.807	.001	.001	3	1
LARGE_INTESTINE	ABCG4 →	+0.304	+3.451	<.001	.005	3	1
LARGE_INTESTINE	ACTL7A →	+0.020	+2.716	.001	.009	3	1
CNS	HES3 →	+0.041	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

HPCAL4 by SNX33 expression — LARGE_INTESTINE

Explore this box plot interactively →