SNX31

Across TCGA patient cohorts, SNX31 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX31-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and Cyclin-B1. Each is linked with SNX31 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX31-to-partner and partner-to-SNX31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SNX31-low versus SNX31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX31→partner) and Y-score (partner→SNX31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.823	+2.720	<.001	.003	3	2
UCEC	C-Raf →	+0.186	+2.000	.001	.030	3	2
UCEC	Cyclin-B1 →	+0.617	+1.906	.006	.016	3	2
UCEC	FoxM1 →	+0.230	+2.415	.027	.003	3	1
UCEC	Rad50 →	-0.265	-3.321	.006	.010	3	1
UCEC	S6_pS240_S244 →	+0.333	+2.415	.042	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caspase-7-cleavedD198 by SNX31 expression — UCEC

Explore this box plot interactively →