SNX3

Across TCGA patient cohorts, SNX3 mutation is significantly associated with the RNA expression of many other genes, with 430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX3-associated genes across cancer lineages are RN7SL457P, TRAJ11, and AP1S3. Each is linked with SNX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX3-to-partner and partner-to-SNX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL457P grouped by SNX3-low versus SNX3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX3→partner) and Y-score (partner→SNX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL457P →	+0.769	+4.602	<.001	.008	3	2
COAD	TRAJ11 →	+1.243	+4.543	<.001	.005	3	2
UCEC	AP1S3 →	+0.840	+3.346	<.001	.005	3	1
UCEC	MRPL39 →	+0.605	+3.595	<.001	.001	3	1
UCEC	EME1 →	+0.643	+3.212	.007	.009	3	1
UCEC	SLC25A28 →	+0.453	+3.353	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 430 associations by consensus.

RN7SL457P by SNX3 expression — COAD

Explore this box plot interactively →