SNX3

Across TCGA patient cohorts, SNX3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX3-associated genes across cancer lineages are A-Raf_pS299, Fibronectin, and HSP70. Each is linked with SNX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX3-to-partner and partner-to-SNX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SNX3-low versus SNX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX3→partner) and Y-score (partner→SNX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.209	-3.169	<.001	.019	3	1
UCEC	Fibronectin →	-0.421	-3.321	.014	.010	3	1
UCEC	HSP70 →	-0.473	-3.321	.024	.010	3	1
UCEC	Ku80 →	+0.325	+2.183	.008	.035	3	1
UCEC	Annexin-1 →	+0.810	+3.019	.003	.019	3	1
UCEC	Tuberin →	+0.407	+2.999	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

A-Raf_pS299 by SNX3 expression — UCEC

Explore this box plot interactively →