SNX3

Across TCGA cell cohorts, SNX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,020 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SNX3-associated GO terms across cancer lineages are Negative regulation of ubiquitin protein ligase activity, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process, and 7-methylguanosine RNA capping. Each is linked with SNX3 in more than 13 cancer types. Because this analysis shows association rather than direction, both SNX3-to-partner and partner-to-SNX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ubiquitin protein ligase activity grouped by SNX3-low versus SNX3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX3→partner) and Y-score (partner→SNX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of ubiquitin protein ligase activity →	+0.311	+0.886	<.001	<.001	3	14
LUNG_NSCLC_LUAD	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.100	+0.817	<.001	<.001	3	13
OVARY	7-methylguanosine RNA capping →	+0.103	+0.629	<.001	.003	3	12
OVARY	7-methylguanosine mRNA capping →	+0.103	+0.629	<.001	.003	3	12
PANCREAS	Phospholipid dephosphorylation →	+0.066	+1.045	<.001	<.001	3	12
BONE	Phosphatidylinositol dephosphorylation →	+0.076	+0.667	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,020 associations by consensus.

Negative regulation of ubiquitin protein ligase activity by SNX3 expression — URINARY_TRACT

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