SNX25

Across TCGA cell cohorts, SNX25 mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX25-associated genes across cancer lineages are OR4M2, MS4A13, and GPRC6A. Each is linked with SNX25 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX25-to-partner and partner-to-SNX25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M2 grouped by SNX25-low versus SNX25-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX25→partner) and Y-score (partner→SNX25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4M2 →	+0.267	+4.887	<.001	.009	3	2
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	2
CNS	GPRC6A →	+0.020	+4.169	<.001	.008	3	1
CNS	OR11H6 →	+0.018	+4.321	<.001	.009	3	1
CNS	WFDC10A →	+0.166	+4.315	<.001	.006	3	1
CNS	CYP2A13 →	+0.032	+5.044	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

OR4M2 by SNX25 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →