SNX20

Across TCGA patient cohorts, SNX20 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX20-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4E. Each is linked with SNX20 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX20-to-partner and partner-to-SNX20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SNX20-low versus SNX20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX20→partner) and Y-score (partner→SNX20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.727	-2.222	<.001	.011	3	2
UCEC	EGFR_pY1068 →	-0.261	-2.222	.014	.011	3	1
UCEC	eIF4E →	+0.216	+2.584	.016	.010	3	1
UCEC	IGFBP2 →	-0.752	-2.999	.006	.035	3	1
UCEC	Ku80 →	+0.211	+1.713	.035	.027	3	1
UCEC	MEK1_p_S217_S221 →	-0.249	-2.000	.031	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ATM by SNX20 expression — UCEC

Explore this box plot interactively →