SNX19

Across TCGA cell cohorts, SNX19 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX19-associated genes across cancer lineages are OR8B12, IQCF5, and DMRTC2. Each is linked with SNX19 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX19-to-partner and partner-to-SNX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by SNX19-low versus SNX19-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX19→partner) and Y-score (partner→SNX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR8B12 →	+0.036	+5.029	<.001	.006	3	2
BLOOD_Leukemia	IQCF5 →	+0.045	+3.464	<.001	.003	3	2
OVARY	DMRTC2 →	+0.017	+4.700	.004	.002	3	2
LARGE_INTESTINE	TMEM106C →	+0.554	+3.169	.002	.009	3	2
PANCREAS	SCYGR10 →	+0.182	+5.000	<.001	.006	3	1
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

OR8B12 by SNX19 expression — LUNG_SCLC

Explore this box plot interactively →