SNX18

Across TCGA pan-cancer cohorts, SNX18 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SNX18 data layer compared with 21 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SNX18 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SNX18 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BLCA, and GBM are the cancer types where SNX18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.972	0.621	.005	14	view →
BLCA	DFS	Median	III,IV	1.000	0.263	.013	13	view →
GBM	DFS	Median	All	0.043	0.257	<.001	12	view →
SKCM	OS	Median	All	0.245	0.781	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SNX18–UCEC (DFS)

Open the UCEC breakdown →