SNX18

Across TCGA pan-cancer cohorts, SNX18 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SNX18 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SNX18 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNX18 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where SNX18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.361	0.916	.008	24	view →
LSCC	OS	Median	III,IV	0.566	0.988	.002	20	view →
LUAD	OS	Quartile	II,III,IV	0.750	0.281	<.001	14	view →
CCRCC	DFS	Median	All	0.891	0.615	.003	14	view →
PDAC	OS	Median	III,IV	0.842	0.399	.009	5	view →
GBM	OS	Median	All	0.736	0.889	.016	3	view →
HNSC	OS	Tertile	III,IV	0.538	0.754	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SNX18–UCEC (DFS)

Open the UCEC breakdown →