SNX18

Across TCGA patient cohorts, SNX18 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX18-associated genes across cancer lineages are EGFR_pY1068, FASN, and INPP4B. Each is linked with SNX18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX18-to-partner and partner-to-SNX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SNX18-low versus SNX18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX18→partner) and Y-score (partner→SNX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.211	-1.459	.009	.012	3	2
UCEC	FASN →	+0.334	+1.807	.008	.025	3	2
COAD	INPP4B →	-0.436	-3.313	.013	.010	3	2
COAD	ASNS →	+0.702	+2.178	<.001	.035	3	2
UCEC	ATM →	-0.567	-2.000	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.374	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

EGFR_pY1068 by SNX18 expression — UCEC

Explore this box plot interactively →