SNX18

Across TCGA cell cohorts, SNX18 mutation is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX18-associated genes across cancer lineages are BRDT, BTBD16, and DIRAS2. Each is linked with SNX18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX18-to-partner and partner-to-SNX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRDT grouped by SNX18-low versus SNX18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX18→partner) and Y-score (partner→SNX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRDT →	+0.174	+4.342	<.001	.002	3	1
BLOOD_Leukemia	BTBD16 →	+0.086	+3.959	<.001	.005	3	1
BLOOD_Leukemia	DIRAS2 →	+0.055	+4.087	.008	.009	3	1
BLOOD_Leukemia	KRT6C →	+0.017	+4.037	<.001	.004	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TEX35 →	+0.198	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

BRDT by SNX18 expression — BLOOD_Leukemia

Explore this box plot interactively →