SNX17

Across TCGA patient cohorts, SNX17 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX17-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with SNX17 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX17-to-partner and partner-to-SNX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SNX17-low versus SNX17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX17→partner) and Y-score (partner→SNX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.630	+2.321	.006	.006	3	2
UCEC	EGFR_pY1068 →	-0.258	-1.807	.012	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.181	-2.321	.009	.034	3	1
UCEC	Ku80 →	+0.215	+1.820	.027	.016	3	1
UCEC	S6_pS240_S244 →	+0.430	+1.807	.010	.027	3	1
UCEC	TFRC →	+0.459	+2.999	.036	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Cyclin-B1 by SNX17 expression — UCEC

Explore this box plot interactively →