SNX14

Across TCGA patient cohorts, SNX14 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX14-associated genes across cancer lineages are eIF4E, FoxM1, and Akt_pT308. Each is linked with SNX14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX14-to-partner and partner-to-SNX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SNX14-low versus SNX14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX14→partner) and Y-score (partner→SNX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.169	+3.472	.021	.002	3	2
UCEC	FoxM1 →	+0.211	+2.070	.018	.001	3	2
UCEC	Akt_pT308 →	+0.478	+2.222	.028	.009	3	2
UCEC	Annexin-1 →	+0.631	+2.827	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.115	-2.880	<.001	.001	3	1
UCEC	eEF2 →	+0.300	+3.459	.015	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by SNX14 expression — UCEC

Explore this box plot interactively →