SNX14

Across TCGA cell cohorts, SNX14 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SNX14-associated genes across cancer lineages are RTL4, C1QB, and C20orf85. Each is linked with SNX14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX14-to-partner and partner-to-SNX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTL4 grouped by SNX14-low versus SNX14-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX14→partner) and Y-score (partner→SNX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RTL4 →	+0.532	+3.866	<.001	.002	3	2
LARGE_INTESTINE	C1QB →	+0.100	+2.994	<.001	.006	3	1
BLOOD_Leukemia	C20orf85 →	+0.023	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KRT85 →	+0.052	+6.124	<.001	<.001	3	1
BLOOD_Leukemia	KRT84 →	+0.576	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CST5 →	+0.456	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RTL4 by SNX14 expression — LUNG_SCLC

Explore this box plot interactively →