SNX12

Across TCGA pan-cancer cohorts, SNX12 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SNX12 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SNX12 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SNX12 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where SNX12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.942	0.749	.006	31	view →
LSCC	OS	Tertile	All	0.699	0.891	.010	8	view →
UCEC	DFS	Median	III,IV	0.499	0.900	.025	8	view →
LUAD	DFS	Median	II,III,IV	0.767	0.933	.034	5	view →
OV	DFS	Median	All	0.563	0.915	.046	4	view →
GBM	OS	Median	All	0.642	0.872	.020	3	view →
PDAC	OS	Median	III,IV	0.743	0.435	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SNX12–CCRCC (OS)

Open the CCRCC breakdown →