SNX11

Across TCGA patient cohorts, SNX11 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX11-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Ku80. Each is linked with SNX11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX11-to-partner and partner-to-SNX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SNX11-low versus SNX11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX11→partner) and Y-score (partner→SNX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.271	-3.169	.031	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.308	.034	.036	3	1
UCEC	Ku80 →	+0.317	+2.335	.007	.020	3	1
UCEC	NF2 →	+0.280	+2.321	.009	.035	3	1
UCEC	Notch1 →	+0.188	+2.820	.007	.035	3	1
UCEC	p62 Lck ligand →	+0.419	+3.179	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by SNX11 expression — UCEC

Explore this box plot interactively →