SNX10

Across TCGA patient cohorts, SNX10 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX10-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Myosin-IIa_pS1943, and p27_pT157. Each is linked with SNX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX10-to-partner and partner-to-SNX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by SNX10-low versus SNX10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX10→partner) and Y-score (partner→SNX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.494	+2.817	.027	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.284	+2.183	.008	.035	3	1
UCEC	p27_pT157 →	-0.061	-3.321	.044	.010	3	1
UCEC	p70-S6K_pT389 →	-0.248	-2.999	.013	.035	3	1
UCEC	p90 RSK_pT359_S363 →	-0.273	-2.999	.010	.035	3	1
UCEC	Tuberin →	+0.454	+3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GSK-3a-b_pS21_S9 by SNX10 expression — UCEC

Explore this box plot interactively →