SNX1

Across TCGA patient cohorts, SNX1 mutation is significantly associated with the RNA expression of many other genes, with 2,247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX1-associated genes across cancer lineages are OR12D2, RPL7AP72, and RN7SL354P. Each is linked with SNX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX1-to-partner and partner-to-SNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D2 grouped by SNX1-low versus SNX1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX1→partner) and Y-score (partner→SNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR12D2 →	+0.044	+6.162	<.001	.002	3	2
READ	RPL7AP72 →	+0.115	+6.681	<.001	<.001	3	2
SKCM	RN7SL354P →	+0.175	+3.988	<.001	<.001	3	2
UCEC	PRMT5 →	+0.652	+2.230	.007	.006	3	2
UCEC	PLEKHJ1 →	+0.744	+2.513	<.001	.001	3	2
UCEC	RNASEH2A →	+0.577	+3.354	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,247 associations by consensus.

OR12D2 by SNX1 expression — BRCA

Explore this box plot interactively →