SNX1

Across TCGA patient cohorts, SNX1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and FOXO3a_pS318_S321. Each is linked with SNX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNX1-to-partner and partner-to-SNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SNX1-low versus SNX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX1→partner) and Y-score (partner→SNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.758	-2.308	<.001	.033	3	3
UCEC	Caspase-7-cleavedD198 →	+0.594	+2.479	.018	.010	3	3
UCEC	FOXO3a_pS318_S321 →	-0.143	-2.449	.006	.019	3	2
UCEC	p27_pT198 →	+0.095	+1.700	.035	.044	3	2
UCEC	Annexin-1 →	+0.675	+3.341	.002	.005	3	2
UCEC	c-Met_pY1235 →	+0.071	+2.009	.024	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by SNX1 expression — UCEC

Explore this box plot interactively →