SNX1

Across TCGA cell cohorts, SNX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,661 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SNX1-associated GO terms across cancer lineages are Regulation of transcription initiation by RNA polymerase II, Regulation of DNA-templated transcription initiation, and mRNA alternative polyadenylation. Each is linked with SNX1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SNX1-to-partner and partner-to-SNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription initiation by RNA polymerase II grouped by SNX1-low versus SNX1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX1→partner) and Y-score (partner→SNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.057	+0.733	<.001	<.001	3	14
URINARY_TRACT	Regulation of DNA-templated transcription initiation →	+0.057	+0.775	<.001	<.001	3	14
KIDNEY	mRNA alternative polyadenylation →	+0.078	+0.629	.004	.001	3	13
OVARY	Regulation of mitotic cytokinesis →	+0.094	+0.563	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.109	+0.934	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.052	+0.817	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,661 associations by consensus.

Regulation of transcription initiation by RNA polymerase II by SNX1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →