SNW1

Across TCGA patient cohorts, SNW1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNW1-associated genes across cancer lineages are HER3_pY1289, PDK1, and Caspase-7-cleavedD198. Each is linked with SNW1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNW1-to-partner and partner-to-SNW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by SNW1-low versus SNW1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNW1→partner) and Y-score (partner→SNW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.083	+2.341	.020	.019	3	2
UCEC	PDK1 →	+0.143	+2.222	.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.708	+1.807	.003	.027	3	2
UCEC	ER-alpha_pS118 →	-0.375	-2.321	.011	.006	3	1
UCEC	ERK2 →	+0.170	+1.807	.032	.027	3	1
UCEC	GAPDH →	+0.467	+1.807	.035	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

HER3_pY1289 by SNW1 expression — UCEC

Explore this box plot interactively →