Across TCGA pan-cancer cohorts, SNTN Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SNTN data layer compared with 20 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SNTN Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNTN expression acts as an unfavorable survival marker.

COAD, STAD, and UCEC are the cancer types where SNTN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.140	0.781	<.001	21	view →
STAD	OS	Median	IV	0.074	0.496	.002	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SNTN tumor-vs-normal RNA expression · all SNTN data types