Across TCGA patient cohorts, SNTN mutation is significantly associated with the RNA expression of many other genes, with 460 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNTN-associated genes across cancer lineages are TPT1P11, TEX29, and C16orf87. Each is linked with SNTN in more than 1 cancer types. Because this analysis shows association rather than direction, both SNTN-to-partner and partner-to-SNTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNTN→partner) and Y-score (partner→SNTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPT1P11 →	+0.158	+2.377	<.001	.008	3	2
UCEC	TEX29 →	+0.647	+3.343	<.001	.005	3	1
UCEC	C16orf87 →	+0.604	+3.502	.003	.002	3	1
UCEC	NTAN1 →	+0.777	+3.201	<.001	.009	3	1
UCEC	ZC3H18 →	+0.682	+3.345	<.001	.005	3	1
UCEC	DBF4B →	+0.535	+3.235	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 460 associations by consensus.

Exploration

SNTN survival (RNA) · tumor vs normal (RNA) · all SNTN data types