SNTB2

Across TCGA patient cohorts, SNTB2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNTB2-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and MEK1. Each is linked with SNTB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNTB2-to-partner and partner-to-SNTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SNTB2-low versus SNTB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNTB2→partner) and Y-score (partner→SNTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.105	-3.143	.013	.018	3	1
UCEC	A-Raf_pS299 →	-0.169	-2.584	<.001	.010	3	1
UCEC	MEK1 →	+0.562	+3.807	<.001	<.001	3	1
UCEC	Notch1 →	+0.204	+2.906	<.001	.001	3	1
UCEC	PDCD4 →	-0.608	-2.222	.002	.011	3	1
UCEC	PKC-a →	+0.478	+3.335	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by SNTB2 expression — UCEC

Explore this box plot interactively →