SNRPD3

Across TCGA pan-cancer cohorts, SNRPD3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SNRPD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNRPD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNRPD3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where SNRPD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNRPD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.823	<.001	12	view →
BLCA	Male	All	+0.913	<.001	11	view →
LIHC	Female	II,III,IV	+1.099	<.001	9	view →
LUSC	Male	II,III,IV	+0.979	<.001	9	view →
STAD	All	II,III,IV	+0.607	<.001	9	view →
COAD	Female	All	+0.534	<.001	9	view →
THCA	Male	All	−0.322	<.001	7	view →
BRCA	All	All	+0.485	<.001	6	view →
CHOL	Male	All	+1.720	<.001	5	view →
KICH	Female	All	−0.916	<.001	5	view →
UCEC	All	II,III,IV	+0.620	.019	4	view →
KIRC	Female	All	+0.267	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SNRPD3–HNSC

Open the HNSC breakdown →