SNRPB2

Across TCGA pan-cancer cohorts, SNRPB2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SNRPB2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNRPB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNRPB2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where SNRPB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNRPB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.935	<.001	12	view →
KIRC	Male	IV	+0.483	<.001	12	view →
BLCA	All	All	+0.575	<.001	10	view →
COAD	Male	All	+0.644	<.001	9	view →
LIHC	Male	II,III,IV	+1.123	<.001	8	view →
STAD	Female	All	+1.245	<.001	7	view →
BRCA	All	III,IV	+0.745	<.001	6	view →
CHOL	Male	All	+2.196	<.001	5	view →
READ	All	III,IV	+1.304	.022	5	view →
LUSC	Male	All	+0.548	<.001	5	view →
KICH	Female	All	−0.663	<.001	4	view →
KIRP	All	II,III,IV	+0.419	.015	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SNRPB2–HNSC

Open the HNSC breakdown →