SNRNP48

Across TCGA pan-cancer cohorts, SNRNP48 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SNRNP48’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SNRNP48 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SNRNP48 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where SNRNP48 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNRNP48 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.387	<.001	8	view →
LUAD	All	III,IV	+0.427	<.001	7	view →
HNSC	All	III,IV	−0.260	.031	6	view →
COAD	All	All	+0.823	.036	4	view →
PDAC	Male	All	−0.661	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SNRNP48–LSCC

Open the LSCC breakdown →