SNRNP48

Across TCGA patient cohorts, SNRNP48 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRNP48-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with SNRNP48 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNRNP48-to-partner and partner-to-SNRNP48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SNRNP48-low versus SNRNP48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRNP48→partner) and Y-score (partner→SNRNP48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.307	-2.321	.014	.035	3	1
UCEC	A-Raf_pS299 →	-0.147	-2.321	.014	.035	3	1
UCEC	FoxM1 →	+0.263	+3.459	.043	.005	3	1
UCEC	INPP4B →	-0.364	-2.999	.025	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-2.308	.025	.036	3	1
UCEC	Tuberin →	+0.486	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by SNRNP48 expression — UCEC

Explore this box plot interactively →