Across TCGA pan-cancer cohorts, SNRNP35 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SNRNP35 data layer compared with 4 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SNRNP35 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNRNP35 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BRCA show a favorable association.
KIRC, UVM, and ACC are the cancer types where SNRNP35 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.