Across TCGA pan-cancer cohorts, SNRNP35 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SNRNP35 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SNRNP35 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SNRNP35 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where SNRNP35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	1.000	0.857	.015	12	view →
LUAD	OS	Median	II,III,IV	0.803	0.448	.013	8	view →
HNSC	OS	Median	III,IV	0.940	0.785	.009	3	view →
GBM	OS	Median	All	0.194	0.572	.036	2	view →
UCEC	DFS	Median	All	0.842	0.949	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SNRNP35 tumor-vs-normal RNA expression · all SNRNP35 data types