SNRNP25

Across TCGA pan-cancer cohorts, SNRNP25 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SNRNP25 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SNRNP25 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNRNP25 expression acts as an unfavorable survival marker, although some lineages such as OV and BRCA show a favorable association.

UVM, ACC, and UCS are the cancer types where SNRNP25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.397	0.797	<.001	103	view →
ACC	OS	Quartile	All	0.714	0.972	<.001	77	view →
UCS	DFS	Median	IV	0.367	0.952	.001	66	view →
SKCM	OS	Tertile	All	0.704	0.837	<.001	46	view →
LAML	DFS	Tertile	All	0.366	0.669	<.001	42	view →
ESCA	OS	Tertile	III,IV	0.279	0.648	.001	36	view →
OV	OS	Quartile	IV	0.598	0.245	.003	34	view →
BRCA	DFS	Tertile	IV	0.764	0.331	.006	33	view →
LIHC	OS	Median	All	0.698	0.857	<.001	33	view →
KICH	DFS	Median	All	0.699	1.000	.009	32	view →
SCLC	OS	Quartile	II,III,IV	0.401	0.807	.013	25	view →
KIRC	OS	Median	All	0.836	0.922	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SNRNP25–UVM (DFS)

Open the UVM breakdown →