SNPH

Across TCGA pan-cancer cohorts, SNPH mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SNPH’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNPH mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SNPH is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where SNPH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNPH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−1.399	.001	6	view →
PDAC	Male	All	−1.208	<.001	6	view →
LSCC	Male	All	−0.777	<.001	6	view →
CCRCC	Female	IV	−1.225	.017	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SNPH–HNSC

Open the HNSC breakdown →