Across TCGA pan-cancer cohorts, SNORD92 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SNORD92’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SNORD92 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD92 is over-expressed in tumor.
LUSC and COAD are the cancer types where SNORD92 tumor–normal differential expression is most reproducible.