Across TCGA pan-cancer cohorts, SNORD91A RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SNORD91A’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SNORD91A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD91A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KIRP, READ, and LUSC are the cancer types where SNORD91A tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD91A RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.