Across TCGA pan-cancer cohorts, SNORD46 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SNORD46’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where SNORD46 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD46 is over-expressed in tumor.
COAD, LUAD, and KIRC are the cancer types where SNORD46 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD46 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.