Across TCGA pan-cancer cohorts, SNORD41 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SNORD41’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SNORD41 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD41 is over-expressed in tumor, although a few such as ESCA and KICH show the opposite, repressed pattern.

COAD, KIRC, and PRAD are the cancer types where SNORD41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.959	.001	5	view →
KIRC	All	All	+0.139	.005	5	view →
PRAD	All	All	+0.143	.015	2	view →
ESCA	Female	All	−0.750	.011	1	view →
KICH	Male	III,IV	−0.537	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SNORD41 RNA expression & survival · all SNORD41 data types