Across TCGA pan-cancer cohorts, SNORD3J RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of SNORD3J’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where SNORD3J RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD3J is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA are the cancer types where SNORD3J tumor–normal differential expression is most reproducible.