SNORD3C

Across TCGA pan-cancer cohorts, SNORD3C RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SNORD3C data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher SNORD3C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD3C expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

MESO, SKCM, and BLCA are the cancer types where SNORD3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.108	0.579	<.001	72	view →
SKCM	DFS	Tertile	II,III,IV	0.199	0.695	<.001	72	view →
BLCA	OS	Tertile	IV	0.196	0.622	<.001	66	view →
ACC	OS	Tertile	All	0.133	0.686	.004	54	view →
LUAD	DFS	Tertile	All	0.300	0.682	.001	54	view →
THYM	DFS	Tertile	All	0.091	0.884	<.001	27	view →
LIHC	DFS	Tertile	II,III,IV	0.080	0.414	.027	27	view →
STAD	OS	Tertile	II,III,IV	0.751	0.355	.027	18	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
LUSC	OS	Tertile	III,IV	0.140	0.664	.016	18	view →
CHOL	OS	Tertile	All	0.155	0.725	.029	9	view →
PCPG	DFS	Tertile	All	0.086	0.846	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SNORD3C–MESO (OS)

Open the MESO breakdown →