Across TCGA pan-cancer cohorts, SNORD36C RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SNORD36C’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where SNORD36C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD36C is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
COAD, LIHC, and LUAD are the cancer types where SNORD36C tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD36C RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.