Across TCGA pan-cancer cohorts, SNORD116-6 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SNORD116-6’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-6 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-6 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.
THCA, STAD, and BRCA are the cancer types where SNORD116-6 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-6 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.