Across TCGA pan-cancer cohorts, SNORD116-3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of SNORD116-3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-3 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA are the cancer types where SNORD116-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.452	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SNORD116-3 RNA expression & survival · all SNORD116-3 data types