SNORD116-22

Across TCGA pan-cancer cohorts, SNORD116-22 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated SNORD116-22 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SNORD116-22 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD116-22 expression acts as an unfavorable survival marker.

KIRC, COAD, and ACC are the cancer types where SNORD116-22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.291	0.575	.001	90	view →
COAD	OS	Tertile	IV	0.042	0.679	<.001	81	view →
ACC	OS	Tertile	All	0.113	0.822	<.001	63	view →
UVM	DFS	Tertile	III,IV	0.079	0.674	.020	54	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	48	view →
SARC	OS	Tertile	All	0.440	0.876	<.001	39	view →
MESO	DFS	Tertile	IV	0.071	0.359	.009	36	view →
LIHC	OS	Tertile	All	0.191	0.707	.006	27	view →
KIRP	OS	Tertile	All	0.688	0.911	.007	21	view →
STAD	OS	Tertile	IV	0.105	0.561	.004	18	view →
PCPG	DFS	Tertile	All	0.481	0.883	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SNORD116-22–KIRC (OS)

Open the KIRC breakdown →